The perils of P-glycoprotein inhibition
نویسندگان
چکیده
منابع مشابه
P 149: Effect of Glycoprotein IIb/IIIa Inhibition on Acute Ischemic Stroke Injuries
Ischemic stroke accounts for about 87 percent of all cases. It occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. It is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. We know that most of the injuries after an acute ischemic s...
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Pharmacokinetic drug-drug interactions often occur at the level of P-glycoprotein (Pgp). To study possible interactions caused by the newer antidepressants we investigated citalopram, fluoxetine, fluvoxamine, paroxetine, reboxetine, sertraline, and venlafaxine and their major metabolites desmethylcitalopram, norfluoxetine, paroxetine-metabolite (paroxetine-M), desmethylsertraline, N-desmethylve...
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P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absorption, permeability, and retention of the drugs, extruding them out of the cells. It is overexpre...
متن کاملp 149: effect of glycoprotein iib/iiia inhibition on acute ischemic stroke injuries
ischemic stroke accounts for about 87 percent of all cases. it occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. it is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. we know that most of the injuries after an acute ischemic s...
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Resistance to chemotherapy in cancer patients has been correlated to the overexpression of the ATP-binding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. We examined the multidrug resistance reversing property of stemofoline derivatives in drug-resistance human cervical carcinoma (KB-V1) and human leukemic (K562/Ad...
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ژورنال
عنوان ژورنال: Hepatology
سال: 1996
ISSN: 0270-9139
DOI: 10.1053/jhep.1996.v24.ajhep0240276